Suggested updated approaches to patient management.

P INTRODUCTION A symposium organized by National Jewish Health and held in Denver, Colorado, on October 8, 2009, investigated the role of intranasal antihistamines for allergic rhinitis. It was titled Rethinking the Treatment of Allergic Rhinitis; the Role of Intranasal Antihistamines: “Me Too Drugs” or a Novel Class? Articles 1 through 4 in this supplement provide detailed information about the biology of histamine and the efficacy and cost-effectiveness of intranasal antihistamines in allergic rhinitis. This publication, based on that symposium, provides a summary of new recommendations and proposes an updated approach to the treatment of allergic rhinitis.